Nebula comes to us from Latin, where it means "mist" or "cloud." In its earliest English uses in the 1600s, nebula was chiefly a medical term that could refer either to a cloudy formation in urine or to a cloudy speck or film on the eye that caused vision problems. It was first applied to great interstellar clouds of gas and dust in the early 1700s. The adjective nebulous comes from the same Latin root as nebula, and it is considerably older, being first used as a synonym of cloudy or foggy as early as the 1300s. Like nebula, however, this adjective was not used in an astronomical sense until the mid-1600s.