For those who think that alcohol and drugs qualify as poisons, the history of intoxicate offers some etymological evidence to bolster your argument. Intoxicate traces back to toxicum, the Latin word for "poison"—and the earliest meaning of intoxicate was as an adjective describing something (such as the tip of an arrow or dart) steeped in or smeared with poison. That meaning dates to the 15th century; the related verb, meaning "to poison," occurs in the 16th. Both senses are now obsolete. Today, we talk about such harmless things as flowers and perfume having the power to intoxicate. Toxicum turns up in the etymologies of a number of other English words including toxic ("poisonous"), intoxicant ("something that intoxicates"), and detoxify ("to remove a poison from"), as well as a number of names for various poisons themselves.