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TOEFL IELTS BNC: 6291 COCA: 8622

mutation

noun

mu·​ta·​tion myü-ˈtā-shən How to pronounce mutation (audio)
1
: a significant and basic alteration : change
2
: umlaut
3
a
: a relatively permanent change in hereditary material that involves either a change in chromosome structure or number (as in translocation, deletion, duplication, or polyploidy) or a change in the nucleotide sequence of a gene's codons (as in frameshift or missense errors) and that occurs either in germ cells or in somatic cells but with only those in germ cells being capable of perpetuation by sexual reproduction
Mutations known to cause disease have been identified in approximately 1000 genes. Alan E. Guttmacher and Francis S. Collins
also : the process of producing a mutation
Microorganisms have been used extensively to study mutation … George A. Wistreich et al.
b
: an individual, strain, or trait resulting from mutation
The worst E. coli bacterium, E. coli 0157:H, a mutation discovered in 1982 that has at least sixty-two subtypes, causes hemorrhagic colitis … Wayne Biddle
mutational
myü-ˈtā-shnəl How to pronounce mutation (audio)
-shə-nᵊl
adjective
mutationally adverb

Example Sentences

The cat's short tail is the result of mutation. The condition is caused by a genetic mutation. The building is a mutation of the original design.
Recent Examples on the Web Having the mutation means HIV can’t latch onto cells, giving natural resistance. Grace Browne, WIRED, 12 Sep. 2022 If the disease killed the animal, would doctors feel obligated to prescribe medication for a child with the same mutation even before symptoms emerged? Amy Dockser Marcus, WSJ, 6 Sep. 2022 But a new study has offered a radically different theory, arguing that side effects such as gas, bloating and intestinal cramps weren’t enough on their own to move the evolutionary needle on the genetic mutation. Rachel Pannett, Washington Post, 28 July 2022 The patient received a blood stem cell transplant at City of Hope in early 2019 for acute myelogenous leukemia from an unrelated donor who has a rare genetic mutation, homozygous CCR5 Delta 32, City of Hope said. Will Linendoll, ABC News, 28 July 2022 But according to an interesting article in The Atlantic, researchers wonder if some of them have a genetic mutation that naturally repels the coronavirus. Teresa M. Hanafin, BostonGlobe.com, 26 July 2022 The patients also had a particular mutation in their KRAS gene. Aayushi Pratap, Forbes, 10 June 2022 If someone has the mutation that causes HD, a child has a 50% chance of inheriting it. Andrew Joseph, STAT, 8 June 2022 That’s because the original omicron strain that swept the world didn’t have the mutation. Laura Ungar, Anchorage Daily News, 27 May 2022 See More

Word History

First Known Use

14th century, in the meaning defined at sense 1

Time Traveler
The first known use of mutation was in the 14th century

Phrases Containing mutation

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