estrange implies the development of indifference or hostility with consequent separation or divorcement.
his estranged wife
alienate may or may not suggest separation but always implies loss of affection or interest.
managed to alienate all his coworkers
disaffect refers especially to those from whom loyalty is expected and stresses the effects (such as rebellion or discontent) of alienation without actual separation.
troops disaffected by hunger
Example Sentences
Recent Examples on the WebSome CFOs who set up meetings with board members may alienate CEOs who see this as going over their head. Kevin Kelleher, Fortune, 12 Aug. 2022 While being too political could alienate Baby Boomers with considerable purchasing power. Kian Bakhtiari, Forbes, 9 Aug. 2022 Roe v Wade could alienate young voters and cost the party seats in upcoming elections. Globe Staff, BostonGlobe.com, 24 June 2022 June 16 – June 30th: Being judgmental will alienate someone who counts near the 18th, so try to lighten up. Katharine Merlin, Town & Country, 16 June 2022 The series may alienate fans of the MCU who are used to svelte Avengers battling evil in billion-dollar productions. Lorraine Alitelevision Critic, Los Angeles Times, 8 June 2022 Senators and aides said talks were helped by leaders in both parties, who gave rank-and-file lawmakers time to reach a deal, and a willingness to set aside policy positions that could alienate either side.New York Times, 22 June 2022 Hogan, a potential 2024 presidential contender, also warned Republicans against rallying behind a Trump ally in the next presidential election, arguing that would alienate many voters. Robert Costa, CBS News, 4 May 2022 Democrats have toiled to win his vote on any piece of their once-ambitious domestic agenda, tailoring their policy moves so as not to alienate him.New York Times, 15 July 2022 See More
Word History
Etymology
borrowed from Latin aliēnātus, past participle of aliēnāre "to transfer (goods, property) to another, lose possession of, render hostile, estrange," verbal derivative of aliēnus "not one's own, of others, foreign, strange" — more at alien entry 1