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antagonist

noun

an·​tag·​o·​nist an-ˈta-gə-nist How to pronounce antagonist (audio)
1
: one that contends with or opposes another : adversary, opponent
political antagonists
2
: an agent of physiological antagonism: such as
a
: a muscle that contracts with and limits the action of an agonist with which it is paired

called also antagonistic muscle

b
: a chemical that acts within the body to reduce the physiological activity of another chemical substance (such as an opiate)
especially : one that opposes the action on the nervous system of a drug or a substance occurring naturally in the body by combining with and blocking its nervous receptor compare agonist sense 2b

Did you know?

On the stage or screen, in a story or a novel, the protagonist is the main character and the antagonist is the opposing one. Pro- and ant- usually mark the good and bad characters, but not always; there may occasionally be an evil protagonist and a good antagonist. In the drama of the real world, it's especially hard to sort out which is which, so we usually speak of both parties to a conflict as antagonists. During a strike, for example, representatives of labor and management become antagonists; they often manage to antagonize each other, and the antagonism often remains after the strike is over.

Synonyms

Example Sentences

They are interested in character first, and in Don, a foul-mouthed psychopath with a hair-trigger temper and buried longings for Gal's wife, they have created a truly scary antagonist. David Ansen, Newsweek, 18 June 2001 In the 1970s researchers discovered that the actions of estrogen and other hormones can be blocked chemically by drugs called hormone antagonists … David Plotkin, Atlantic, June 1996 If the new comptroller is a true antagonist of the seamy bond market practices he decried in the campaign, why has he installed as his first deputy the public finance director from the Dinkins administration who was Holtzman's accomplice in each of those deals. Wayne Barrett, Village Voice, March 1994 As in that film, Kopple not only draws an intimate portrait of the protagonists and antagonists in the strike, but also deftly locates the workers' struggle within a broad context of economic and political forces. Frank Thompson, Film Comment, January/February 1991 please name the novel's hero and his antagonist his antagonist in the boxing match See More
Recent Examples on the Web Caffeine is an antagonist for the neurotransmitter adenosine. Larry Greenemeier, Scientific American, 9 Nov. 2010 The main antagonist of the movie was written as this kind of beefy, tough, 45-year-old guy. Simon Thompson, Forbes, 9 Aug. 2022 But it’s not the main antagonist of Doctor Strange 2. Chris Smith, BGR, 28 Apr. 2022 Forty-one years ago, the key antagonist of the X-Men, Magneto, was revealed to be a Holocaust survivor. Samantha Baskind, Smithsonian Magazine, 3 Mar. 2022 More important, the flourishing commercial-image world was an antagonist that the Kamoinge Workshop sought to refute. Christopher Knight, Los Angeles Times, 28 July 2022 Naloxone is an opioid antagonist that rapidly reverses an opioid overdose. Joshua Cohen, Forbes, 5 July 2022 Frosty conditions can be the absolute antagonist to your daily driving companion. Dalvin Brown, The Courier-Journal, 6 Jan. 2022 After all, in the comics, Starfox is an Eternal, Clea marries Doctor Strange, and Hercules starts out as a Thor antagonist before the two become friends. Adam B. Vary, Variety, 8 July 2022 See More

Word History

Etymology

see antagonize

First Known Use

1555, in the meaning defined at sense 1

Time Traveler
The first known use of antagonist was in 1555

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