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upstream

adverb or adjective

up·​stream ˈəp-ˈstrēm How to pronounce upstream (audio)
1
: in the direction opposite to the flow of a stream
2
: in or to a position within the production stream closer to manufacturing processes
make most of its money upstream, selling cheap crude … to refineries John Quirt
3
biochemistry : toward the beginning of a series of cellular processes : preceding a linked molecular event occurring in a sequence
Many signaling pathways possess intrinsic negative feedback by which a downstream event in a pathway turns off an upstream event. Harvey Lodish et al.

Example Sentences

Recent Examples on the Web Chinook salmon haven’t been able to reach the McCloud River since 1942, when the construction of Shasta Dam blocked the fish from swimming upstream and sealed off their spawning areas in the cold mountain waters near Mt. Shasta. Ian Jamesstaff Writer, Los Angeles Times, 16 July 2022 Last month, a pre-monsoon flash flood, triggered by a rush of water from upstream in India’s northeastern states, hit Bangladesh’s northern and northeastern regions, destroying crops and damaging homes and roads. Julhas Alam And Wasbir Hussain, Anchorage Daily News, 18 June 2022 One is that federal officials made an unprecedented decision last month to delay water released from upstream at Lake Powell, to preserve the Glen Canyon Dam’s hydropower-producing capabilities. Angela Fritz, CNN, 26 May 2022 On Wednesday, the official level of the Rhine at Emmerich am Rhein, a town just upstream from the Dutch border, fell to a historic low, shattering a record set in October 2018. New York Times, 18 Aug. 2022 During a good year in Bristol Bay, a surge of more than 100 million pounds of sockeye salmon fights its way upstream, spawns, and dies. Ned Rozell, Anchorage Daily News, 2 July 2022 The plummeting level of Lake Powell upstream on the Colorado River -- the nation's second-largest reservoir -- is affecting species in the river downstream and at the park according to Nebel. Rachel Ramirez, CNN, 2 July 2022 Other reserves upstream would not be able to help much this year because of weak snowpack and a lack of rain. Meryl Kornfield, Anchorage Daily News, 23 July 2022 The company’s segments include upstream, downstream and chemical. Charles Rotblut, Forbes, 26 Apr. 2022 See More

Word History

First Known Use

1681, in the meaning defined at sense 1

Time Traveler
The first known use of upstream was in 1681

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