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- insides 47
- comparably 120
substance
noun
sub·stance ˈsəb-stən(t)s 
1
a
: essential nature : essence
b
: a fundamental or characteristic part or quality
c
Christian Science : god sense 1b
2
a
: ultimate reality that underlies all outward manifestations and change
b
: practical importance : meaning, usefulness
Synonyms
Example Sentences
The pancreas secretes a substance called insulin. The floor was covered with a white, powdery substance that turned out to be flour. heroin and other illegal substances He had a history of substance abuse. When has he ever said anything of substance? The results of the study give substance to their theory. the substance of my argument See More
Recent Examples on the Web The county also promised to establish 300 additional substance use and mental health beds, according to a copy of the term sheet. 
Benjamin Oreskes, Los Angeles Times, 12 Sep. 2022 Her mother, Crystal Sorey, and father had substance abuse issues, the agency said. Marlene Lenthang, NBC News, 9 Sep. 2022 At the same time, the voices of both people who use drugs and people with substance-use disorders are absent from the chapter. Melissa Gira Grant, The New Republic, 6 Sep. 2022 One doctor who signed the letter, Stephanie Pierce, is the medical director of a clinic for pregnant women with substance-use disorders at the University of Oklahoma Health Sciences Center. Cary Aspinwall, al, 1 Sep. 2022 One doctor who signed the letter, Stephanie Pierce, is the medical director of a clinic for pregnant women with substance-use disorders at the University of Oklahoma Health Sciences Center. Amy Yurkanin, Washington Post, 1 Sep. 2022 However, the resident says Clenney’s substance use caused her demeanor to change. Andrea Marks, Rolling Stone, 26 Aug. 2022 According to a 2020 report from the homeless services agency, more than 14,000 unhoused people in the county have serious mental illnesses and more than 15,000 are grappling with substance abuse issues. Nick Watt, CNN, 24 Aug. 2022 Provost cited Renfro’s fear of them, substance abuse issues and a difficult childhood involving an alcoholic parent, an ADHD diagnosis at the age of 5, and exposure to domestic violence. Zaz Hollander, Anchorage Daily News, 18 Aug. 2022 See More
Benjamin Oreskes, Los Angeles Times, 12 Sep. 2022 Her mother, Crystal Sorey, and father had substance abuse issues, the agency said. Marlene Lenthang, NBC News, 9 Sep. 2022 At the same time, the voices of both people who use drugs and people with substance-use disorders are absent from the chapter. Melissa Gira Grant, The New Republic, 6 Sep. 2022 One doctor who signed the letter, Stephanie Pierce, is the medical director of a clinic for pregnant women with substance-use disorders at the University of Oklahoma Health Sciences Center. Cary Aspinwall, al, 1 Sep. 2022 One doctor who signed the letter, Stephanie Pierce, is the medical director of a clinic for pregnant women with substance-use disorders at the University of Oklahoma Health Sciences Center. Amy Yurkanin, Washington Post, 1 Sep. 2022 However, the resident says Clenney’s substance use caused her demeanor to change. Andrea Marks, Rolling Stone, 26 Aug. 2022 According to a 2020 report from the homeless services agency, more than 14,000 unhoused people in the county have serious mental illnesses and more than 15,000 are grappling with substance abuse issues. Nick Watt, CNN, 24 Aug. 2022 Provost cited Renfro’s fear of them, substance abuse issues and a difficult childhood involving an alcoholic parent, an ADHD diagnosis at the age of 5, and exposure to domestic violence. Zaz Hollander, Anchorage Daily News, 18 Aug. 2022 See More Word History
Etymology
Middle English, from Anglo-French, from Latin substantia, from substant-, substans, present participle of substare to stand under, from sub- + stare to stand — more at stand
First Known Use
14th century, in the meaning defined at sense 1a
Time Traveler
The first known use of substance was in the 14th century Phrases Containing substance
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