estrange implies the development of indifference or hostility with consequent separation or divorcement.
his estranged wife
alienate may or may not suggest separation but always implies loss of affection or interest.
managed to alienate all his coworkers
disaffect refers especially to those from whom loyalty is expected and stresses the effects (such as rebellion or discontent) of alienation without actual separation.
troops disaffected by hunger
Example Sentences
the troops were disaffected by the extension of their tours of duty
Recent Examples on the WebSanders-Warren backers see Mr. Trump as a symptom of deeper woes, of the desperation of long-struggling voters disaffected by the recent economic prescriptions of both parties. Jacob M. Schlesinger, WSJ, 30 Jan. 2020 Dina Litovsky for The New York Times Here’s at least one sign that some young adults are disaffected with dating apps. Jennifer Miller, New York Times, 6 Sep. 2019 Yang has honed in on a message of the Fourth Industrial Revolution, touted the need for a nationwide universal basic income and boasted about his ability to reach voters who have become disaffected by national politics. Rebecca Morin, USA TODAY, 13 Dec. 2019 One danger for the prime minister is that on election day conservative voters disaffected by the looming corruption charges could abandon him for other right-wing parties, or for an opposition bloc.Washington Post, 8 Apr. 2019 And that adds to its appeal for supporters disaffected from the moneyed elites who run the former British colony, organizers say. Christopher Bodeen, chicagotribune.com, 18 June 2019 In their run to the last four, England re-engaged with a fanbase disaffected by decades of failure at international tournaments, most notably in a humiliating exit to Iceland at Euro 2016. Chicago Tribune, chicagotribune.com, 12 July 2018 Many militants are disaffected by poverty and unemployment, and some have reportedly traveled to regional countries, including Kenya, Tanzania and Somalia, for religious or military training, according to a study released last month in Maputo.Washington Post, 11 June 2018 And for the seasonally disaffected among us, that glorious big bang can’t come soon enough. Kathryn Shattuck, New York Times, 5 Apr. 2018 See More