: having lost former closeness and affection : in a state of alienation from a previous close or familial relationship
her estranged husband [=her husband with whom she no longer lives]
Social workers may try to resolve conflicts between estranged siblings. Jonathan D. Rockoff
He had taken out a life insurance policy on his estranged wife just weeks before her murder … David Fisher
… it's kind of shameful to admit your idea of unwinding in front of the TV is watching somebody's entire family get murdered by their greedy, estranged uncle. Lauren Zupkus