Pfizer will gain Oxbryta, Global Blood’s therapy for sickle-cell disease that sold about $195 million last year and the companies see as a potential blockbuster.BostonGlobe.com, 8 Aug. 2022 Pfizer is in advanced talks to acquire Global Blood Therapeutics, the maker of a drug for sickle-cell disease, for about $5 billion.WSJ, 6 Aug. 2022 Complications from sickle-cell disease and HIV and the hepatitis alphabet. Vanessa A. Bee, Harper's BAZAAR, 8 July 2022 Certain health conditions, such as cystic fibrosis or sickle-cell anemia, are well understood to be genetic, and some consumer DNA test kits may be capable of identifying the genes associated with those kinds of diseases. Kimberly Hickok, Popular Mechanics, 24 May 2022 The dancers circled a group of performers who held up yellow flowers to form the symbol of the Workers’ Party of Korea – a hammer, brush, and sickle. Hyung-jin Kim And Tong-hyung Kim, The Christian Science Monitor, 15 Apr. 2022 He is often depicted with a sickle, his worship and festivals connected to the harvest. Josh St. Clair, Men's Health, 16 Apr. 2022 One poignant picture shows the bloody silhouette of Russian President Vladimir Putin, a hammer cleaving his head and a sickle plunged into his eye. Phil Mccausland, NBC News, 14 Apr. 2022 Bluebird approached her to help design its sickle-cell trial. Dhruv Khullar, The New Yorker, 22 Mar. 2022
Adjective
Pfizer agreed to buy Global Blood Therapeutics for $5.4 billion, a deal that would give the big drugmaker a foothold in the treatment of sickle-cell disease.WSJ, 9 Aug. 2022 Montefiore Medical Center is a hospital system in New York that cares for large numbers of patients with sickle-cell disease. Dhruv Khullar, The New Yorker, 22 Mar. 2022 For some patients, a coronavirus infection can aggravate a seemingly unrelated condition—a COVID fever tips an elderly woman with a urinary-tract infection into delirium; a bout of diarrhea dehydrates a man admitted with sickle-cell disease. Dhruv Khullar, The New Yorker, 16 Jan. 2022 Now, Vertex will take over that role for the sickle-cell treatment, on a global basis — a decision made in large part because the company already has a large-scale manufacturing and sales network in place.BostonGlobe.com, 20 Apr. 2021 On Thursday, Nesbitt said the city’s scientific advisory committee decided not to sort this group by age, in part because many patients with HIV and sickle-cell anemia do not live to 50.Washington Post, 18 Feb. 2021 And anything that puts strain on your body can cause a sickle-cell pain crisis.Health.com, 1 July 2020
Verb
The result is hemoglobin S—a misshapen version that causes red blood cells to sickle. Dhruv Khullar, The New Yorker, 22 Mar. 2022 Blood cells filled with fetal hemoglobin do not sickle. Gina Kolata, BostonGlobe.com, 11 Jan. 2020 Blood cells filled with fetal hemoglobin do not sickle.New York Times, 11 Jan. 2020 See More
Word History
Etymology
Noun
Middle English sikel, from Old English sicol, from Latin secula sickle, from secare to cut — more at saw
First Known Use
Noun
before the 12th century, in the meaning defined at sense 1