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cystic fibrosis

noun

: a common, progressive hereditary disease of exocrine gland function that typically appears in infancy or early childhood and is marked by the accumulation of thick, sticky mucus in the ducts and passages of various organs and especially those of the lungs and pancreas resulting in shortness of breath, persistent cough, chronic respiratory infection, pancreatic enzyme insufficiency, faulty digestion, malnutrition, and poor growth

Note: The genetic mutation linked to cystic fibrosis causes disruption in the movement of chloride ions and water across cell membranes resulting in mucus that is thick and sticky instead of thin and slippery and in elevated concentrations of sodium and chloride in sweat and saliva. Cystic fibrosis occurs especially in people of northern European ancestry and is inherited as an autosomal recessive trait requiring that both parents pass on a copy of the defective gene on a chromosome other than a sex chromosome.

… children with cystic fibrosis are born with healthy lungs; only later do their lungs become plugged with mucus and incur infections. The Journal of the American Medical Association
Cystic fibrosis is the most common lethal inherited disorder in the United States. Approximately 30,000 people in this country have inherited two defective copies of the CF gene and thus the disease; approximately 1 in 20 Americans has just one copy of the gene and is a carrier of the disease. Joe Palca
—abbreviation CF

Example Sentences

Recent Examples on the Web Decades ago, most cystic fibrosis sufferers died by the age of 5. BostonGlobe.com, 11 Oct. 2021 In the deal announcement, McMurry said he was moved to make the new edition free as a tribute to his son Peter, who died in 2019 after fighting cystic fibrosis. Derek Newton, Forbes, 11 Aug. 2022 The citation said his models had provided new insights into the effects of particulate air pollution on human health and the risk factors for ailments including cystic fibrosis, obesity and sleep apnea, among many other things. James R. Hagerty, WSJ, 28 Jan. 2022 Ben Auspitz, who worked at CombinatoRx and is chief executive of IDRx, said the company was also inspired by successful drug combination regimens, such as those developed by Boston biotech Vertex to tackle cystic fibrosis. Anissa Gardizy, BostonGlobe.com, 2 Aug. 2022 She's openly spoken about becoming legally blind and her son having cystic fibrosis. Alicia Vrajlal, refinery29.com, 13 July 2022 For example, in cystic fibrosis, the disruption comes in the form of thick mucus that blocks the digestive enzymes in the pancreas from reaching the small intestine, according to the Mayo Clinic. Jessica Toscano, SELF, 8 July 2022 For most of his life, he was hospitalized twice a year as a result of his cystic fibrosis. Andrew Joseph, STAT, 22 June 2022 Medical marijuana has been legal in Connecticut for a decade and may be used for more than three dozen conditions ranging from cancer to cystic fibrosis and epilepsy. Stephen Singer, Hartford Courant, 16 June 2022 See More

Word History

First Known Use

1938, in the meaning defined above

Time Traveler
The first known use of cystic fibrosis was in 1938

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