Middle English noxius, borrowed from Latin noxius "guilty, delinquent, harmful, injurious" (derivative of noxa "injurious behavior, harm, mischief") + -us -ous; noxa derivative (perhaps with -s- as a desiderative suffix) from the base of nocēre "to damage (things), injure, harm (persons)," going back to Indo-European *noḱ-éi̯e- "destroy" (with semantic weakening in Latin), whence also Sanskrit nāśáyati "(s/he) destroys," causative derivatives from a verbal base *neḱ- "disappear, pass out of existence, perish," whence, with varying ablaut grades, Sanskrit náśyati "(s/he) is lost, perishes," Avestan nąsat̰ "has gone away, is lost," Tocharian B näk- "destroy," (in middle voice) "disappear, be destroyed"