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annealed; annealing; anneals
1
a
: to heat and then cool (a material, such as steel or glass) usually for softening and making less brittle
also : to cool slowly usually in a furnace
b
: to cause two complementary strands of nucleic acid (such as DNA or RNA) to join by hydrogen bonding
also : to induce the binding of a genetic primer (see primer entry 2 sense 3) to a complementary single-stranded nucleic acid by slowly cooling single strands obtained from the heating and separation of double-stranded DNA or RNA
The primers are annealed to the single strands when the local temperature is reduced to between 50 and 65 C. 
Andrew J. DeMello
Andrew J. DeMello During PCR, fragments are heated so they will separate into single strands. A short nucleotide sequence called a primer is then annealed to each original template. George M. Church
George M. Church 
Did you know?
Anneal Has a Fiery History
If you were looking for a saying to apply to the word anneal, it might be "everything old is new again." The word was originally associated with one of the oldest technologies of humankind: fire. It derives from the Old English word onǣlan, which was formed from the Old English root āl, meaning "fire." In its earliest known uses, anneal meant simply "to set on fire." That sense has become obsolete, however, and nowadays anneal is associated with metalworking and glasswork as well as a much more recent technological development. As addressed in sense 3 of the definition, it has come to be used in the context of DNA research, in reference to the heating and cooling of double-stranded nucleic acid.
Example Sentences
Recent Examples on the Web For hybrid algorithms, the back and forth between classical and annealing worlds means regular communications with the D-Wave hardware, which helped motivate the company to try to reduce the latency of those communications. John Timmer, Ars Technica, 1 Oct. 2019 Further Reading D-Wave announces the next generation of its quantum annealerThe other challenge annealing faces is that classical algorithms are constantly improving. John Timmer, Ars Technica, 1 Oct. 2019 Solutions are downhill One way to compute a solution to a problem is called annealing. Chris Lee, Ars Technica, 13 June 2019 The slow cooling of the glass allows it to anneal, relieving internal stresses and improving durability. Jay Bennett, Popular Mechanics, 14 Feb. 2018 Before and after the Eagles’ organized team activities last spring, Nelson Agholor retreated to his hometown for a series of training sessions with an old friend and mentor that would anneal his mind as much as his body. Mike Sielski, Philly.com, 8 Oct. 2017 To make the object, the copper was alternately hammered and annealed—a process of heating metal and allowing it to cool slowly. Brigit Katz, Smithsonian, 12 June 2017 See More
John Timmer, Ars Technica, 1 Oct. 2019 Further Reading D-Wave announces the next generation of its quantum annealerThe other challenge annealing faces is that classical algorithms are constantly improving. John Timmer, Ars Technica, 1 Oct. 2019 Solutions are downhill One way to compute a solution to a problem is called annealing. Chris Lee, Ars Technica, 13 June 2019 The slow cooling of the glass allows it to anneal, relieving internal stresses and improving durability. Jay Bennett, Popular Mechanics, 14 Feb. 2018 Before and after the Eagles’ organized team activities last spring, Nelson Agholor retreated to his hometown for a series of training sessions with an old friend and mentor that would anneal his mind as much as his body. Mike Sielski, Philly.com, 8 Oct. 2017 To make the object, the copper was alternately hammered and annealed—a process of heating metal and allowing it to cool slowly. Brigit Katz, Smithsonian, 12 June 2017 See More Word History
Etymology
Middle English anelen to set on fire, from Old English onǣlan, from on + ǣlan to set on fire, burn, from āl fire; akin to Old English ǣled fire, Old Norse eldr
First Known Use
1664, in the meaning defined at transitive sense 1a
Time Traveler
The first known use of anneal was in 1664 👨🏻🏫 Mr. Ng 韋氏詞典 📚 – mw.mister5️⃣.net
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