:without being prevented by (something):despite — used to say that something happens or is true even though there is something that might prevent it from happening or being true尽管
He failed the test in spite of all his studying.尽管他学习很努力,可考试还是没及格。
She went ahead in spite of the snow.尽管下着雪,她依旧继续前行。
They made it on time in spite of the fact that they got a flat tire.尽管汽车轮胎泄了气,他们还是准时到达了目的地。